Sleep, Lean Mass/Muscle Support, Immunity

Sermorelin is a synthetic (man-made) version of a naturally occurring substance that causes release of growth hormone from the pituitary gland. Growth hormone is naturally produced by the pituitary gland and is necessary for growth in children.

Benefits reported by users include:

• Improved memory, focus, concentration, and stamina

• More energy

• Better sleep with fewer sleep disturbances

• Improved skin elasticity

• Healthier heart and improved immune system

• Increased bone density and bone strength

• Increased muscle mass

• Increased ability to rebuild lost muscle mass

• Increase in sex drive, sexual potency, and frequency

• Improved cognitive functioning

CJC-1295 and Ipamorelin are peptides that act as growth hormone secretagogues, designed to stimulate the pituitary gland to release growth hormone (GH) into the bloodstream.

CJC-1295: This peptide generates prolonged, moderate increases in Growth Hormone levels maintaining natural GH pulsatility.

Ipamorelin: This peptide causes short, large GH spikes, mimicking the effects of ghrelin. It activates cells in the anterior pituitary gland and other brain areas to regulate various physiological processes, including metabolism, sleep, and cognitive functions.

Benefits

• Weight Loss

• Muscle Growth and Strength

• Improved Sleep Quality

• Increased Energy

• Anti-Aging Effects

Injuries, Healing, Intestinal Problems

BPC-157 is the short-form name of “Body Protection Compound 157,” a synthetic formulation derived from 15 amino acids derived from the stomach’s gastric juices. The peptide is known to activate our body’s growth hormone receptors and increase blood flow which may enhance healing. BPC-157 helps accelerate the body’s ability to heal from injuries and decrease inflammation particularly with injuries affecting the skin, muscles, tendons, and ligaments.

Patients with the following conditions have also successfully used this peptide to improve their gastrointestinal symptoms:

• Inflammatory bowel syndrome

• Crohn’s disease

• Ulcerative colitis

• Leaky gut syndrome

• Acid reflux

• Ulcers

• Fistulas

• Malabsorption syndrome

• Chronic constipation or diarrhea

Weight Loss, Cardiovascular & Metabolic Health

Semaglutide is a selective GLP-1 receptor agonist, while Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Retatrutide is an investigational peptide that acts as a triple agonist, binding and activating the glucagon, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) receptors.

Glucagon-like peptide-1 (GLP-1) agonists (also known as GLP-1 receptor agonists, incretin mimetics, or GLP-1 analogs) represent a class of medications used to treat type 2 diabetes mellitus and obesity. These medications interact with the parts of the brain that reduce appetite and signal a feeling of fullness. Another role of GLP-1 is to prompt the body to produce more insulin, which reduces blood glucose (sugar).

Clinical Evidence

Semaglutide/Wegovy: At week 68, semaglutide-treated participants lost an average of 14.9% of baseline weight, compared with 2.4% for those assigned to placebo (untreated).

Tirzepatide/Mounjaro: A phase 3 randomized, controlled clinical trial demonstrated that tirzepatide led to a 20 percent reduction in body weight over 72 weeks.

Retatrutide has been found to produce the greatest weight loss among GLP-1 receptor agonists and co-agonists. It outperformed other agents like tirzepatide and semaglutide in terms of mean weight reduction

Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women. Bremelanotide is administered intranasally or as a subcutaneous injection. Specifically PT-141 is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, or problems within the relationship.

Hypoactive sexual desire disorder (HSDD) is the most prevalent female sexual health disorder. Hypoactive sexual desire disorder (HSDD) is a persistent deficiency or absence of sexual fantasies and desire resulting in significant distress or interpersonal difficulty. Women with this disorder may display a lack of motivation for sexual activity, reduced responsiveness to erotic cues, a loss of interest during sexual activity, and avoidance of situations that could lead to sexual activity.

Gonadorelin is a peptide that stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), helping maintain natural testicular function in men undergoing testosterone supplementation. It supports healthy sperm production and testicular size, preventing testicular atrophy often associated with long-term testosterone therapy. This makes it a valuable addition for those seeking to optimize their hormone therapy while preserving fertility and overall testicular health, & one of many ways that Defiance Health is set apart as the most experienced, thorough hormone clinics in Colorado & the USA.